This analysis demonstrated that the group of patients with high expression of RAB27B (Z-score > 0) exhibited significantly lower OS rates compared with those in the low expression group (Z-score < 0) in both the ccRCC (P = 0.00179, Fig 1A, left panel) and pRCC (P = 0.00407, Fig 1A, right panel) cohorts. This evidence concerns the gene RAB27B and nonpapillary renal cell carcinoma.