Our panel for ultra-deep targeted sequencing contains diagnostically important mutated genes in colorectal cancer that are highly mutated among patients with this malignancy: APC, TP53, KRAS, BRAF, PIK3CA, SMAD4, ATM, ARID1A, ACVR2A, and TCF7L2 [11–13]. The gene discussed is SMAD4; the disease is colorectal cancer.