Furthermore, a meta-analysis of eleven studies also proved that a low PNI is a poor prognostic factor for OS and disease-free survival (DFS) in HCC, whereas a high PNI is a favourable prognostic factor and is associated with better clinical predictors, such as lower AFP, lower recurrence rates, smaller tumor size, and earlier TNM tumor stage [41]. This evidence concerns the gene AFP and hepatocellular carcinoma.