Actually, Tsuboi’ team reported that, among the 1827 recombinant proteins produced in the wheat germ lysate and evaluated with 51 plasma samples from adults leaving in Malian low malaria transmission area, the P. falciparum HMGB1 and HMGB2 proteins encompassed a marked immune reactivity with a potential protective efficacy elicited by the corresponding antibodies. The gene discussed is HMGB1; the disease is malaria.