According to our previous study, ART could protect the blood-brain barrier by activating sphingosine 1 phosphate receptor 1/phosphatidylinositol 3 kinase (S1pR/PI3K) signaling pathway, and artesunate alleviated neurologic impairment and brain edema 24h after an established animal model of subarachnoid hemorrhage [8]. The gene discussed is S1PR1; the disease is subarachnoid hemorrhage.