And our data revealed that ART inhibited the transcriptional function of FOXO-3a by promoting its phosphorylation, downregulated P27kip1 and promoted neural stem cell proliferation in the infarcted cortex through PI3K/Akt signaling pathway, subsequently alleviating injury and improving functional recovery of ischemic stroke (Figures 4, 6). This evidence concerns the gene CDKN1B and ischemic stroke.