Recently there have been several subtype-specific trials including AYA patients, such as a phase II trial with the EZH2 inhibitor (tazemetostat) for patients with advanced epithelioid sarcoma, and a placebo-controlled randomized phase II study with cediranib for patients with metastatic alveolar soft part sarcoma (CASPS).49,50. This evidence concerns the gene EZH2 and epithelioid sarcoma.