In this study, we identified angiogenic genes that were abnormally expressed in HCC by analyzing HCC-related mRNA sequences in TCGA and ICGC databases, and then we identified expression characteristics of four angiogenic genes (ENFA3, EGF, MMP3 and AURKB) that were significantly associated with HCC prognosis using univariate Cox regression and LASSO Cox regression. This evidence concerns the gene MMP3 and hepatocellular carcinoma.