HF of different etiology in animal models is associated with increased mitochondrial fragmentation, decrease in pro-fusion factors, and increase in pro-fission factors: OPA1, MFN1, and Drp1 (94); OPA1, MFN1, MFN2, Drp1, and FIS1 (87); MFN2 and Drp1 (95) and MFN2 (Drp1 was reduced) (42). This evidence concerns the gene OPA1 and hydrops fetalis.