MTNR1B and polycystic ovary syndrome: In addition, authors also found rs10830963 and rs10830962 SNPs in MTNR1B gene were associated with female polycystic ovary syndrome (PCOS) (Li, Shi, You, Wang, & Chen, 2011; Yang, Yang, & Cheng, 2016), this result suggests that SNPs in MTNR1B gene may affect integrity of ovarian function to regulate reproductive activity.