miRNA‐646 has been reported to be down‐regulated in many human cancers and is involved in the development of many malignant tumours as a tumour suppressor gene, including colon cancer, pancreatic cancer, gastric cancer, lung cancer, osteosarcoma and clear cell kidney cancer.23, 24, 25, 26, 27, 28. This evidence concerns the gene ENSG00000280371 and colonic neoplasm.