miRNA‐646 has been reported to be down‐regulated in many human cancers and is involved in the development of many malignant tumours as a tumour suppressor gene, including colon cancer, pancreatic cancer, gastric cancer, lung cancer, osteosarcoma and clear cell kidney cancer.23, 24, 25, 26, 27, 28. The gene discussed is ENSG00000280371; the disease is osteosarcoma.