Inclusion of statin drugs into a pharmacotherapeutic regimen of medications aimed at combatting atherosclerosis [e.g., medications for inhibiting the absorption of intestinal cholesterol (ezetimibe), fibrates to lower serum triglycerides, antiplatelet drugs to prevent the formation of blood clots, newer proprotein convertase subtilisin kexin type 9 (PCSK9) inhibitors, etc.] should increase the pharmacological effectiveness of this approach and improve long-term outcomes in patients with CVD. This evidence concerns the gene PCSK9 and atherosclerosis.