Both the mRNA and protein levels of NLRP3 in peripheral blood mononuclear cells (PBMCs) obtained from CAD patients are higher than non-CAD controls, which suggest that the transcription and protein levels of the NLRP3 inflammasome have a significant positive correlation with elevated plasma levels of IL-1β and IL-18 [41]. The gene discussed is IL18; the disease is coronary artery disorder.