Another study reported that bone marrow depletion of caspase-1 in LDL-R−/− deficient rats consuming a high-fat diet had a significant reduction in atherosclerotic plaque formation, while other studies have shown that silencing IL-1α, IL-1β, and caspase-1 genes in ApoE−/− mice can significantly diminish the development of atherosclerosis [60]. The gene discussed is APOE; the disease is atherosclerosis.