In this regard, Menu P. et al. reported contradictory results; ApoE−/− mice with a double-knockout each of NLRP3−/−, Asc−/−, and caspase-1−/− and consuming a high-fat diet for 11 weeks neither influenced the progression of atherosclerosis, nor the progression in cell infiltration into the intima. This evidence concerns the gene CASP1 and atherosclerosis.