The animals which received anti-Nogo antibodies (8.4 mg/2 ml) intrathecally, from day 2/3 to 14, via osmotic pumps revealed a significantly higher success rate in the pellet grasping task already 2 weeks after stroke compared to animals without treatment (“anti-Nogo i.t.” vs “spontaneous recovery” group, repeated-measures 2-way ANOVA with post hoc Bonferroni, P < 0.05, Fig. 1B). The gene discussed is RTN4; the disease is stroke disorder.