To date, few U(SPIO)-MRI and TSPO-PET imaging studies are available in EAE induced by proteolytic protein (PLP) in SJL/J female mice, a model that leads to spinal cord but also widespread cerebral pathology [12, 13] and mimics relapsing remitting MS (RR-MS, the most frequent human MS phenotype). This evidence concerns the gene TSPO and relapsing-remitting multiple sclerosis.