MBP and myeloid sarcoma: In conclusion, despite these limitations, our study demonstrates the sensitivity of the [18F]DPA-714 for in vivo imaging of brain microglia/macrophage activation during the acute phase in PLP-EAE mice similar to what reported in the spinal cord of MBP-EAE rats [40] and in the brain grey and white matter of cuprizone-MS mice during demyelination periods [41].