Kimura et al. analyzed 34 patients with intestinal BD and reported HLA-B51 positivity, high CRP levels, high white blood cell count, and bloody stool as refractory factors that led to the administration of corticosteroids or treatment involving drugs, including 5-ASA or more aggressive treatments (immunomodulatory drugs and TNF inhibitors) [26]. This evidence concerns the gene CRP and Behcet disease.