Thus, An et al. (2016) intercalated doxorubicin into the adenosine-5′-triphosphate (ATP) responsive DNA scaffold, which was subsequently condensed and protected with a glutathione responsive polymer pOEI and functionalized with the LAT1 substrate 3CDIT (Fig. 4L) responsible for targeting the drug to tumour cells (93). Here, LAT is linked to neoplasm.