Most relevant to the current analysis, we conducted a 12-month intervention in persons with moderate-to-severe AD, showing that an aloe polymannose multinutrient complex (APMC) improved their immune function (according to TNF-α, IL-2, IL-4, and vascular endothelial growth factor [VEGF]) and increased the production of adult stems according to CD14+ by just under 300% [21]. Here, TNF is linked to Alzheimer disease.