CD276 and ductal breast carcinoma in situ: ROC analysis indicated that B7-H3 immunostaining could distinguish high grade from low grade DCIS with an AUC of 0.96 (95% CI 0.91, 1.00), and high grade from intermediate grade DCIS with an AUC of 0.73 (95% CI 0.57, 0.89) for all tissues sampled.