Overall, B7-H3 expression was significantly (P < 0.001) higher in high-grade DCIS (H-Score = 159.1 ± 87.6) compared with normal tissue (H-Score = 10 ± 8.2), low grade DCIS (H-Score = 20.8 ± 17.7), and intermediate grade DCIS (H-Score = 87.1 ± 69.5). The gene discussed is CD276; the disease is ductal breast carcinoma in situ.