Current studies have revealed that nanoparticles have multifaceted functions for (a) working as an effective substitute for generation and transduction of CAR- (chimeric antigen receptor-) T cell, (b) inculcating tumor-suppressing activity to TAM (tumor-associated macrophages), and (c) knocking down Kras oncogene addition by using nano-Crisper-Cas9 delivery system [42]. Here, KRAS is linked to neoplasm.