As shown in Figure 4, AOSD patients with a systemic pattern had significantly higher frequencies of CLEC5A in granulocytes and plasma IL-18 levels (median 73.3%, IQR 70.4-78.2%; 2554 pg/ml, IQR 815-12554 pg/ml; respectively) compared with those with a chronic articular pattern (66.4%, IQR 62.9-72.5%, p < 0.05; 622 pg/ml, IQR 441-940 pg/ml, p < 0.01; respectively). Here, IL18 is linked to adult-onset Still disease.