IL2 and tuberculosis: However, additional biomarkers such as IL-2, IL-5, IL-10, IL-1RA, and MCP have been studied for their ability to differentiate between the LTBI and active TB [8], and it is believed that the cellular and immune profile expressed during tuberculous infection depends to a great extent on the stage of disease, i.e., LTBI or active, where immune biomarkers present in blood could have the ability to differentiate with greater precision between both stages [9].