The levels of the typical Th1 cytokines (IFN-γ and IL-2), Th2 cytokines (IL-4 and IL-5), and IL-6 in the culture supernatants of splenocytes upon stimulation were significantly elevated in mice immunized with MAP-TB as compared with mice immunized with MAP-B or PBS (Figure 4). This evidence concerns the gene IL4 and tuberculosis.