CPNE3 and type 2 diabetes mellitus: In the RNA-seq results, genes were directly with neutrophil activation, like the expression of adhesion molecules like SELL, SELP, PECAM1, and related ligands or receptors, such as CXCR1, CXCR2, calcium-binding protein (S100A8, S100A11, and S100A12), bone marrow stromal cell antigen 2 (BST2), heat shock protein family A member 1A (HSPA1), and Copine 3 (CPNE 3) were increased in type 2 diabetes (Figure 6).