In the above most enriched pathways, especially cytokine-cytokine receptor interactions and cell adhesion molecule (CAM) signaling, the majority of the genes associated with the two pathways were upregulated in type 2 diabetes, such as chemokine (C-X-C motif) ligand (CXCL7, CXCL4), C-X-C chemokine receptor type (CXCR1, CXCR2), also named Interleukin 8 Receptor (IL8RA, IL8RB), as well as cell adhesion molecules integrin subunit alpha M (ITGAM), L-selectin (SELL), P-selectin (SELP), plate endothelial cell adhesion molecule-1 (PECAM1), and P-selection glycoprotein ligand-1 (PSGL-1). The gene discussed is CXCR1; the disease is type 2 diabetes mellitus.