The adhesion genes ITGAM (CD11b), PECAM1, SELL, and SELP and the receptor PSGL-1 were upregulated in type 2 diabetes, and the mRNA levels of SELL and SELP were also increased in neutrophils from patients with type 2 diabetes, as assessed by real-time PCR; however, there was no difference in PECAM1 levels in neutrophils between patients and healthy controls. The gene discussed is SELPLG; the disease is type 2 diabetes mellitus.