IL6 and neoplasm: During the cancer development, myeloid-derived suppressor cells (MDSCs), including macrophages, dendritic cells (DCs), and myeloid precursors, play a role in promoting tumor progression and angiogenesis, via suppressing T cells and NK cells by producing cytokines such as IL-6, IL-10, and TGF-β and also differentiating into TAMs under hypoxic conditions [9].