Accumulated evidence indicates that TME consists of a myriad of protumoral immune cells, such as neutrophils, tumor-associated macrophages (TAMs), CD4+ T helper-2 cells, and regulatory T cells (Tregs), which are the essential parts shaping the immune suppression environment, enabling tumor cell survival and metastasis, furthermore promoting the evasion of the immune destruction [3] (Table 1). Here, CD4 is linked to neoplasm.