VEGFA and neoplasm: The most widely utilized hypoxia imaging PET/SPECT tracer is 1-(2-nitroimidazolyl)-3-[18F]fluoro-2-propanol (FMISO) [101], which was found to provide better quality images of the hypoxia tumor area in humans at 4 hours, with an accurate reflection of HIF-a and VEGF [102].