TP53 and hepatocellular carcinoma: The co-expression experiments showed that the level of TP53 expression was strongly correlated with those of the two miRNAs in HCC patients (miR-221-3p: r = 0.313, P-value: 7.16E−10; miR-375: r = 0.036, P-value: 4.59E−1) (Figs. 5E and 5F).