In separate random effects models, AF burden was significantly related to a history of stroke (β 43.09, CI (23.22; 62.95); p < 0.0001), brain natriuretic peptide (BNP) levels (β 0.05, CI (0.02; 0.09); p=0.005), end-diastolic (β 0.49, CI (0.23; 0.74); p=0.0003) as well as end-systolic (β 0.25, CI (0.05; 0.46); p=0.02) left atrial volume, left atrial ejection fraction (β −0.42, CI (−0.76; −0.09); p=0.01), E-wave (β 37.93, CI (13.98; 61.89); p=0.002), and deceleration time (β −0.1, CI (−0.16; −0.05); p=0.0002) (Table 2). This evidence concerns the gene NPPB and stroke disorder.