AKT1 and myocardial infarction: Another therapeutic target against MI which was uncovered by Tian et al. is the role of BAY 60–6583 which reduces myocardial infarct size in C57BL/6 mice after 40 min ischemia and 1 hour of reperfusion and also decreasing the infiltration of M1 macrophage neutrophils as well as increasing the accumulation of M2 macrophages in the perfused myocardium via P13K/AKt pathways [201].