A study reported that the expression of collagen types I and III and HSP47 were increased, and the matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs) led to abnormal expression during the process of conjunctival matrix remodeling in a patient with epidermolysis bullosa acquisita (EBA) [6]. The gene discussed is SERPINH1; the disease is acquired epidermolysis bullosa.