TheCD14++IL1β subpopulation appeared to be part of theinflammatory landscape of COVID-19, since these cells increased in ERS stage.Virus-induced IL-1β production in monocytes is mediated via a caspase-1 pathway.Multiple microbial components, including viral RNA, are thought to trigger assemblyof the inflammasome and consequent caspase-1 activation28, which may give areasonable explanation for the presence of IL1β+monocytes in ERS patients. The gene discussed is IL1B; the disease is COVID-19.