Notably, genes associatedwith CD4+ T cells had relatively high expressionlevels of inflammation-related genes and were significantly upregulated in theCOVID-19 patients (Fig. 4d).CD4+ T cells had high expression levels ofinflammatory genes, including FOS, JUN, KLF6,and S100A8 in patients in the ERS of COVID-19(Fig. 4e). This evidence concerns the gene JUN and COVID-19.