NFKB1 and viral infectious disease: Interesting results were also noticed for downregulated genes in chickens fed diet Y. The GSEA analysis pointed out a significant enrichment of several genes sets, most of them being related to viral infection response (e.g. double-stranded RNA activated pathway, interferon signalling pathway), antigen recognition (e.g. activation of T-cell receptors, toll-like receptor pathway, T-cell cytotoxic surface proteins), stress response (e.g. NF-κB activation), apoptosis induction (FAS signalling pathway), and inflammation (signal transduction through interleukin-1 receptor).