Conversely, upregulation of MMP-13 and stimulation of the AKT-pathway mediated by MMP-13 by Interleukin-32 enhances the motility and invasion of osteosarcoma cells, confirming the key role of this metalloproteinase in lung metastases [5, 20] (Table 1). This evidence concerns the gene MMP13 and osteosarcoma.