During the EMT process of HCC cells, it was found that when HCC cells were treated with the miR-140-3p mimic or siRNA-GRN, GRN (granulin) expression would be downregulated and the expression of the MAPK signaling pathway-related genes also decreased, like N-cadherin and vimentin; however, the expression of E-cadherin is exactly the opposite. The gene discussed is GRN; the disease is hepatocellular carcinoma.