Activation of the NLRP3 inflammasome by these mechanisms has been discovered in various disorders, including metabolic syndrome, type 2 diabetes, atherosclerosis, gout, reperfusion injury of the heart, neurodegeneration, such as Alzheimer's disease, chronic kidney diseases, and more, and more studies suggest that NLRP3 inflammasome is involved in the development of cardiovascular diseases. Here, NLRP3 is linked to chronic kidney disease.