NLRP3 and gout: Activation of the NLRP3 inflammasome by these mechanisms has been discovered in various disorders, including metabolic syndrome, type 2 diabetes, atherosclerosis, gout, reperfusion injury of the heart, neurodegeneration, such as Alzheimer's disease, chronic kidney diseases, and more, and more studies suggest that NLRP3 inflammasome is involved in the development of cardiovascular diseases.