Herein, the aims of this study were to evaluate the circulatory WISP1 concentration in pregnant women with overweight/obesity and GDM in a cross-sectional study, to examine the discriminatory power of WISP1 on the copresence of prepregnancy overweight/obesity and GDM, and to clarify the relationship between the WISP1 level and clinical cardiometabolic parameters. This evidence concerns the gene CCN4 and Obesity.