SLC5A2 and acute kidney injury: On the other hand, we previously showed that the SGLT2 inhibitor ipragliflozin does not affect the body fluid volume (ECW, intracellular water [ICW] and TBW) in euvolemic animal models [6, 13], and recent meta-analyses did not demonstrate an increase in acute kidney injury with SGLT2 inhibitors [14, 15].