Th17 cells exert an effect by secreting IL-17A, IL-17F, IL-26, and TNF in psoriasis, forming a feedforward inflammatory network with KCs, activating STAT-1 and NF-κB signaling pathway, and inducing keratinocytes (KCs) to secrete several pro-inflammatory factors. The gene discussed is NFKB1; the disease is psoriasis.