Table 1 listed the major clinicopathological characteristics including age, menopausal status, histological type, T stage, N status, ER status, and HER2 gene status grouped by tumor-stroma ratio. The TSR correlated with the histological type (P=0.044) but not with age (P=0.636), menopausal status (P=0.927), T stage (P=0.966), N status (P=0.327), histological grade (P=0.302), ER status (P=0.164), and HER2 gene status (P=0.943) (Table 1). This evidence concerns the gene ESR1 and neoplasm.