POMC and adenoma: In the secretory adenoma group, GH-secreting adenomas (66, 47.8%), ACTH-secreting adenomas (35, 25.4%), prolactinomas (24, 17.4%), TSH-secreting adenomas (8, 5.8%), FSH-secreting adenomas (1, 0.7%), and GH/PRL-secreting adenomas (4, 2.9%) were clinically identified and then confirmed by pathologists using immunohistochemistry.