To further investigate the effects of miR-129-5p on NSCLC development, A549 and H460 cells were transfected with si-NC + NC inhibitor, si-KCNQ1OT1 + NC inhibitor or si-KCNQ1OT1 + miR-129-5p inhibitor. This evidence concerns the gene KCNQ1OT1 and non-small cell lung carcinoma.