The presence of S100 protein, including the S100B subtype present on LCs, has already been demonstrated on various skin cells both in physiological and pathological conditions (such as melanocytes, melanoma, or chondroid syringoma); hence, the results of the studies utilizing the more specific anti-CD1a present only on the surface of LCs and other antigen-presenting cells might be the most reliable. Here, S100B is linked to eccrine mixed tumor of skin.