Using ATPase method of staining LCs, Alcalay et al. analysed the sensitivity of LCs to simulated solar radiation in patients with BCC and revealed that exposure to radiation resulted in a significant decrease of the number of ATPase-positive LCs [22], while Mardones et al. used anti-CD1a antibody to compare the areas of epidermis overlying and adjacent to the BCC and showed the lower density of LCs in the epidermis overlying the tumour; Rotsztejn et al. demonstrated a decreased number of LCs in BCC using the same staining [23, 24]. This evidence concerns the gene DNAH8 and skin basal cell carcinoma.