In concordance with our results, Strohbuecker et al. and Bergmann et al. previously showed that HMGB1 is significantly increased in the serum of patients with psoriasis; they have also suggested that the presence of HMGB1 may impact the composition of chronic inflammation in psoriasis which might have implications for Treg and Th17cells [15, 28]. The gene discussed is HMGB1; the disease is psoriasis.