Given that human pathologies such as psoriasis, lupus, and scleroderma [12, 14, 15] are associated with reduced TNIP1 protein levels, as opposed to being expression null, we modeled cells deficient in TNIP1 protein and their responses to limiting amounts of likely encountered cell membrane receptor signaling molecules to assess for possible synergistic effects of the two conditions. Here, TNIP1 is linked to scleroderma.