NPPB and Cowden syndrome 1: The increased concentrations of these cytokines correlated with the severity of circulatory failure, as indicated by their negative correlation with blood pressure, and positive correlation with norepinephrine treatment and NT-proBNP during the first 2 days, which is in full agreement with the above-cited reports showing a direct link between the degree of acute inflammation and the severity of hemodynamic deterioration in CS.