This observation may be of relevance considering the associated hearing loss phenotypes observed in individuals with severe and LoF variants in COL27A1. Interestingly, in family HOU2809 composed of three affected siblings with STLS but molecularly diagnosed and clinically evaluated as adults (ages 33, 39, and 48 years), all three affected individuals presented with bilateral hearing loss with onset after 30 years of age. The gene discussed is COL27A1; the disease is hearing loss disorder.