In Tbx21−/− (T-bet) Rag−/− mice, IL-17A+ ILC3s were shown to drive Helicobacter typhlonius triggered colitis.69 IL-17A derived from CCR6+ ILC3s was identified to be important for airway hyperactivity in the context of high-fat diet (HFD)-induced asthma, in which ILC3s were stimulated by IL-1β released from MNP in a Nlrp3 inflammasome-dependent manner.199. This evidence concerns the gene IL17A and colitis.