In this context, IL-25 and TSLP were both reported to repress ILC3 activation and IL-22 production in the context of colitis and therefore exacerbate intestinal inflammation.20,229 Moreover, cytokines promoting type 1 immune responses, such as IFN-I, IFN-γ or IL-27 were found to inhibit ILC2s and consequently limit allergic inflammation.31,132 Similar findings were reported for the skin in the context of contact hypersensitivity, in which depletion of ILC2s resulted in an exaggerated type 1 immune response.230. Here, IL22 is linked to colitis.