Although alteration of numerous chemokines with pro- or anti-oncogenic effect were reported, CXCL3 and its CXCR2 receptor have been poorly investigated in PDAC.30 Further explorations would be interesting given that CXCL3–CXCR2 axis is associated with tumour cell proliferation and migration, notably in prostate and breast cancer.31–33. This evidence concerns the gene CXCR2 and neoplasm.