Upregulated genes in the stroma were related to cell cycle, cell migration and ECM remodelling, and included numerous soluble and transcription factors linked to cancer (e.g. ADAMTS12, CXCL3, FAP, ITGB4, LAMC2, LIF, MET, RUNX1, SFN, TNFSF9) (Supplementary Table 5). The gene discussed is CXCL3; the disease is cancer.