As our result seems be in contrast with precious study which showed that high Immunoscore was associated with favourable prognosis, the underlying difference was that our HCC-IHC classifier was mainly composed of suppressive immune cell marker cluster, such as CD68, CD66b, and PD-1.12,44,45 Thus lower HCC-IHC classifier, which was in parallel with lower suppressive immune cell markers, is equal to hotter immune microenvironment or high Immunoscore, which was in line with more positive immune markers, which accentuated the finding in Galon and colleagues’ work. This evidence concerns the gene CD68 and hepatocellular carcinoma.