The aim of the Result of Obesity on Vaccine Efficacy (ROVE) Study was to utilize a nonrandomized controlled trial to evaluate, in otherwise healthy adults, the effect of obesity (BMI ≥30) versus nonobesity (22 ≤ BMI ≤ 25) on humoral responses to PPSV23 in relation to STING1 genotypes. This evidence concerns the gene STING1 and obesity disorder.