Like βlac-TT, βlac-TT(767AAA769) and βlac-TT(767RKK769) trafficked to the perinuclear vesicles void of synaptic vesicle 2C (SV2C), a synaptic vesicle marker protein, while HCC/A2 trafficked to SV2C-enriched perinuclear vesicles (Fig. 5) (12). This evidence concerns the gene SV2C and hepatocellular carcinoma.