TYMS and neoplasm: The most promising parameters are the tumor marker carcinoembryonic antigen (CEA), fibrinogen, genetic polymorphisms in epithelial growth factor receptor (EGFR) and thymidylate synthase (TS), bcl-2/bax and cyclooxygenase (COX)-2, clinical T-size, statin use, and the distance of the primary tumor from the anal verge [4, 6–13].