While pS129-α-syn positively correlated with age in PD group (r = 0.384, P < 0.01), aging was also associated with increased levels of CSF TNF-α in both PD and asymptomatic carriers groups (r = 0.362, P < 0.01, r = 0.492, P < 0.01, respectively). The gene discussed is TNF; the disease is Parkinson disease.