When we explored correlations between α-syn species and the AD biomarkers, we found that t-α-syn positively correlated with Aβ-40 and Aβ-42 in the asymptomatic LRRK2 group (r = 0.568, P < 0.01, r = 0.485, P < 0.05). The gene discussed is LRRK2; the disease is Alzheimer disease.